Gene information
Official symbol SLC6A4
Official full name solute carrier family 6 member 4
Gene type protein-coding gene
Chromosome17q11.2
Alias symbol5-HTT; SERT1
Previous symbolHTT; OCD1
Gene familySolute carriers
Resources
Entrez Gene 6532
HGNC HGNC:11050
Ensembl ENSG00000108576
Vega OTTHUMG00000132751
UCSC uc060dmn.1
GO terms: 83 records
GO Description Category LogP Number of genes Detail
GO:0000149 SNARE binding GO Molecular Functions -1.99483321 5 More
GO:0001505 regulation of neurotransmitter levels GO Biological Processes -3.63969141 10 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003779 actin binding GO Molecular Functions -9.68875312 26 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006814 sodium ion transport GO Biological Processes -1.68216350 6 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007613 memory GO Biological Processes -4.31484432 16 More
GO:0007617 mating behavior GO Biological Processes -3.11015029 4 More
GO:0007620 copulation GO Biological Processes -2.88014031 3 More
GO:0007623 circadian rhythm GO Biological Processes -8.17635164 13 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010008 endosome membrane GO Cellular Components -3.11007663 16 More
GO:0014074 response to purine-containing compound GO Biological Processes -9.77915279 26 More
GO:0015844 monoamine transport GO Biological Processes -2.92503639 5 More
GO:0015850 organic hydroxy compound transport GO Biological Processes -17.9399475 23 More
GO:0019098 reproductive behavior GO Biological Processes -2.82460817 4 More
GO:0019905 syntaxin binding GO Molecular Functions -1.99479187 4 More
GO:0022804 active transmembrane transporter activity GO Molecular Functions -1.58321714 10 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032526 response to retinoic acid GO Biological Processes -5.75287026 10 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035176 social behavior GO Biological Processes -3.23240493 5 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0035725 sodium ion transmembrane transport GO Biological Processes -1.81540720 5 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045787 positive regulation of cell cycle GO Biological Processes -4.54703082 15 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0046620 regulation of organ growth GO Biological Processes -13.2396968 26 More
GO:0046621 negative regulation of organ growth GO Biological Processes -3.90789529 8 More
GO:0046683 response to organophosphorus GO Biological Processes -8.57801626 23 More
GO:0046873 metal ion transmembrane transporter activity GO Molecular Functions -1.47457965 10 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048640 negative regulation of developmental growth GO Biological Processes -7.44784067 20 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050805 negative regulation of synaptic transmission GO Biological Processes -5.05172294 12 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051015 actin filament binding GO Molecular Functions -8.37111928 17 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051703 biological process involved in intraspecies interaction between organisms GO Biological Processes -3.23240493 5 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071300 cellular response to retinoic acid GO Biological Processes -4.69230219 12 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098657 import into cell GO Biological Processes -2.13294972 7 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098794 postsynapse GO Cellular Components -5.82876983 23 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0098889 intrinsic component of presynaptic membrane GO Cellular Components -4.93822812 13 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:2000177 regulation of neural precursor cell proliferation GO Biological Processes -5.62902185 15 More
Drug-Gene interaction
view
Related drugs: 52 records
Drug name Interaction type Source PMID View
4-methylthioamphetamine DTC 19717215 view
alcohol PharmGKB 31595439 view
amitriptyline inhibitor TdgClinicalTrialTEND 16079297176895321474447615877309953782116032412873663016140280 view
amoxapine inhibitor TdgClinicalTrialTEND 95378217984281 view
berberine PharmGKB 21647174 view
buprenorphine PharmGKB 29333880 view
bupropion PharmGKB 21658141 view
citalopram inhibitor TdgClinicalTrialTEND 159554122704993911300876105469827548008111804981006348995378211950060221546862179160591961606110188639 view
clomipramine inhibitor TdgClinicalTrialTENDPharmGKB 17471183106136181086798512647451930542195378211269531614993096 view
clozapine PharmGKB 20452607 view
cocaine inhibitor TdgClinicalTrialTEND 83028521535138612057823953782110366604 view
dapoxetine inhibitor TdgClinicalTrial view
desipramine inhibitor TdgClinicalTrialTEND 16300628953782112464448942236116140280 view
desvenlafaxine inhibitor TdgClinicalTrialTEND 176736061667563919698900199192951908687520944767 view
dexfenfluramine inhibitor TdgClinicalTrialTEND 1451534115266556146751031132541311259539 view
doxepin inhibitor TdgClinicalTrialTEND 191799419537821 view
duloxetine inhibitor TdgClinicalTrialTEND 96695061474447619480470153168381665083015892657161992411603241227841001248119218408530204323241733595115695064 view
escitalopram inhibitor TdgClinicalTrialTEND 128765511266539224424469179160591238770719616061127199601154373712232544 view
evodiamine PharmGKB 21647174 view
fluoxetine inhibitor TdgClinicalTrialNCITEND 172890861148761095378211175235217215106173565731733595117486443 view
fluvoxamine inhibitor TdgClinicalTrialTEND 12721776122083131517006420687077111665211269531611304754185681101181751716316311 view
haloperidol PharmGKB 2702343720031235 view
imipramine inhibitor TdgClinicalTrialTEND 150564831062455311746710108693877548008953782111513817 view
levomilnacipran inhibitor TdgClinicalTrial view
lumateperone inhibitor TdgClinicalTrial 30449883 view
methadone PharmGKB 29333880 view
methamphetamine negative modulator TdgClinicalTrial 176731992022681519607959 view
methylphenidate inhibitor TdgClinicalTrialTEND 104144381019993917154506 view
milnacipran inhibitor TdgClinicalTrialTEND 168691173005901 view
minaprine inhibitor TdgClinicalTrialTEND 96940221713928417016423 view
morphine PharmGKB 32432768 view
nefazodone inhibitor TdgClinicalTrialTEND 76499707475971947284595378219098663 view
nortriptyline inhibitor TdgClinicalTrialTEND 14744476146044481685545195378211102792412640215 view
olanzapine PharmGKB 2385957420031235 view
ondansetron PharmGKB 21247998 view
paroxetine inhibitor TdgClinicalTrialTEND 109803261153012827032980108693872333822495378211102792410987842 view
phentermine inhibitor TdgClinicalTrialTEND 1467510317459426166449041638055010458725 view
protriptyline inhibitor TdgClinicalTrialTEND 969495796729049537821147659599282598767026 view
pseudoephedrine inhibitor TdgClinicalTrial 15189772 view
quetiapine PharmGKB 2385957420031235 view
ribavirin PharmGKB view
risperidone PharmGKB 2385957420031235 view
sertraline negative modulatorbinderinhibitor TdgClinicalTrialTEND 121515561560689311243491126474511057504512955294187518969537821169637948664165 view
sibutramine inhibitor TdgClinicalTrialTEND 1667855119475780111529841568525015382615124175431092970418671470172846211594486917544870 view
solriamfetol TdgClinicalTrial view
tedatioxetine TdgClinicalTrial view
tesofensine TdgClinicalTrial 17112503 view
tramadol inhibitor TdgClinicalTrialTEND 159667689558603100428016427041 view
trazodone inhibitor TdgClinicalTrialTEND 953782120095366 view
trimipramine inhibitor TdgClinicalTrialTEND 953782116388933 view
venlafaxine inhibitor TdgClinicalTrialTEND 197285731722471719238127930542195378211591040216140280108845611175018015695064 view
vortioxetine inhibitor TdgClinicalTrial 21486038 view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
NG_011747.2:g.3628_3670dup genomics myocardial infarction[diagnosis] myocardial infarction Fumeron F et al. Circulation. 2002
NG_011747.2:g.3628_3670dup genomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Nakatani D et al. Am Heart J. 2005
NG_011747.2:g.3628_3670dup genomics depression[prognosis (bad)] acute myocardial infarction Nakatani D et al. Am Heart J. 2005
NG_011747.2:g.3628_3670dup genomics myocardial infarction[diagnosis] myocardial infarction Xia DS et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009
sodium-dependent serotonin transporter proteomics myocardial infarction[diagnosis] myocardial infarction Sauer WH et al. Circulation. 2003
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